Preparation Method of Dodecyl Dimethyl Benzyl Ammonium Chloride

Jun 18, 2019

Dodecyl dimethyl benzyl ammonium chloride is synthesized through the following steps:

 

Synthesis of dodecyl bromide:
Heat dodecyl alcohol to 100°C and introduce dry hydrobromic acid gas. After the reaction, remove the excess hydrobromic acid using a water wash and treat with concentrated sulfuric acid. Mix the resulting dodecyl bromide with an equal volume of 50% methanol and add 25% ammonia solution to achieve an alkaline reaction indicated by phenolphthalein. Extract the lower layer with 50% methanol, dry with calcium chloride, filter, and vacuum distill to collect the fraction at 134-136°C (0.8 kPa). The yield is 87%.

 

Synthesis of dimethyl dodecylamine hydrobromide:
Dissolve dodecyl bromide in a slightly excess solution of dimethylamine and keep at room temperature for 13-15 days to obtain dimethyl dodecylamine hydrobromide. Dissolve it in ether, wash with water, extract with 5% HCl, salt out with concentrated sodium hydroxide, dry at 111-114°C (0.33 kPa), and then subject to vacuum distillation. The yield is 47%.

 

Synthesis of Benzalkonium chloride:
Take 213 parts of dimethyl dodecylamine and add 126.5 parts of Benzyl Chloride. Heat the mixture at a temperature below 100-110°C for 2 hours. The resulting light yellow viscous liquid will solidify upon cooling. The yield is above 90%. This product has extremely low toxicity and does not exhibit cumulative toxicity. It has minimal irritability to the skin and mucous membranes and does not corrode metals, rubber, or plastic.

 

Need Help? Chat with us

leave a message
For any request of information or technical support, fill in the form. All fields marked with an asterisk* are required.
Submit
Looking for FAQs?
Contact us #

Our hours

Mon - Fri: 9:00 AM - 5:30 PM
Sat - Sun closed
(all hours are Eastern Time)

home

products

Contact Us