Preparation Method of Dodecyl Dimethyl Benzyl Ammonium Chloride
Jun 18, 2019Dodecyl dimethyl benzyl ammonium chloride is synthesized through the following steps:
Synthesis of dodecyl bromide:
Heat dodecyl alcohol to 100°C and introduce dry hydrobromic acid gas. After the reaction, remove the excess hydrobromic acid using a water wash and treat with concentrated sulfuric acid. Mix the resulting dodecyl bromide with an equal volume of 50% methanol and add 25% ammonia solution to achieve an alkaline reaction indicated by phenolphthalein. Extract the lower layer with 50% methanol, dry with calcium chloride, filter, and vacuum distill to collect the fraction at 134-136°C (0.8 kPa). The yield is 87%.
Synthesis of dimethyl dodecylamine hydrobromide:
Dissolve dodecyl bromide in a slightly excess solution of dimethylamine and keep at room temperature for 13-15 days to obtain dimethyl dodecylamine hydrobromide. Dissolve it in ether, wash with water, extract with 5% HCl, salt out with concentrated sodium hydroxide, dry at 111-114°C (0.33 kPa), and then subject to vacuum distillation. The yield is 47%.
Synthesis of Benzalkonium chloride:
Take 213 parts of dimethyl dodecylamine and add 126.5 parts of Benzyl Chloride. Heat the mixture at a temperature below 100-110°C for 2 hours. The resulting light yellow viscous liquid will solidify upon cooling. The yield is above 90%. This product has extremely low toxicity and does not exhibit cumulative toxicity. It has minimal irritability to the skin and mucous membranes and does not corrode metals, rubber, or plastic.