• How Many Generations Have Quaternary Ammonium Salt Biocides Been Developed?

    How Many Generations Have Quaternary Ammonium Salt Biocides Been Developed?

    Jul 21, 2021
    The development of quaternary ammonium salt pesticides has gone through at least seven generations. The first-generation product is alkyl dimethyl benzyl ammonium chloride, with optimal fungicidal effect achieved when the alkyl chain length is C12-C16. The second-generation product is a derivative of the first generation, which can be obtained through substitution reactions on the benzene ring or the quaternary nitrogen. The third-generation product is dialkyl dimethyl ammonium chloride, which has improved synthesis process and production costs compared to the previous two generations, and exhibits strong bactericidal ability against Gram-negative bacteria. The fourth-generation product is a mixture of the first and third generations, with 4 to 20 times higher fungicidal effect than the previous three generations. It has strong anti-interference ability, low toxicity, and a lower price. The fifth-generation product is a diquaternary ammonium salt containing two nitrogen atoms, characterized by excellent fungicidal effect, low toxicity, good water solubility, and broad biological activity. The sixth-generation product is polymeric quaternary ammonium salt, which has even lower toxicity and a milder bactericidal action, making it more valuable for medical applications such as disinfection of contact lenses and personal care products. The seventh-generation product is a mixture of the first, second, and sixth generations, leveraging the synergistic enhancement principle. Its fungicidal effect is superior to a single component. m=1, n=0, R7 is a long chain, it is the first generation of single chain quaternary ammonium salts m=1, n=0, R7 is a long chain (containing aromatic units), it is the second generation single chain quaternary ammonium salt m=1, n=0, R1 or R2 is a long chain, it is the third generation double chain quaternary ammonium salt m=1, n=1, R7 is a long chain, and R1 or R2 is a long chain, it is the 5th generation double quaternary ammonium salt m>2, n=0, R7 is a long chain (capable of containing aromatic hydrocarbons), it is the 6th generation polyquaternary ammonium salt  

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